課程資訊
課程名稱
環境衛生風險評估
RISK ASSESSMENT FOR ENVIRONMENTAL HEALTH 
開課學期
98-2 
授課對象
公共衛生學院  環境衛生研究所  
授課教師
林嘉明 
課號
EH7012 
課程識別碼
844 M1150 
班次
 
學分
全/半年
半年 
必/選修
選修 
上課時間
星期三7,8(14:20~16:20) 
上課地點
公衛211 
備註
總人數上限:30人 
Ceiba 課程網頁
http://ceiba.ntu.edu.tw/982raeh 
課程簡介影片
 
核心能力關聯
本課程尚未建立核心能力關連
課程大綱
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課程概述

教學目標:本課程透過閱讀、討論、練習等方式,使學生熟悉經由環境與職業
暴露化學有害物的健康風險評估,尤其強調方法論與實務應用。

93學年度第二學期(24/02/2010-23/06/2010)環境衛生(健康)風險評估課程大綱
課程編號:環境衛生風險評估 844M1150
授課教師:林嘉明 TEL:02-23123456 ext 8365
課程助教:林士鈞

日期 內容* 備註*
2/24 Introduction(Risk, health risk assessment, risk management)
3/03 Chemical hazards and risk acceptability
3/10 Exposure, exposure assessment, exposure scenario and dose
3/17 Quantifying exposure dose
3/24 Calculation of human dose rate and dose from human and animal studies
3/31 Quantization of response; Calculation of excess risk
4/07 Holiday
4/14 Midterm examination
4/21 Excess risk and dose: Tolerance distribution models
4/28 Excess risk and dose: Mechanistic models
5/05 Life time risk estimate for sub-experimental dose range
5/12 Acceptable concentration
5/19 Acceptable concentrations-risk analysis method for non-threshold
toxicants
5/26 Acceptable concentrations-safety factor (uncertainty factor) method
for threshold toxicants
6/02 Acceptable concentrations (Benchmark dose derived reference
concentration, RfC)-benchmark dose method for threshold toxicants
6/09 Application of software to health risk assessment –Monte Carlo
Simulation; Demonstration of a case study
6/23 Final examination


參考書籍
1. William H. Hallenbeck: Quantitative risk assessment for
environmental and occupational health (2nd Edition), Lewis
Publisher, New York, 1993
2. Jack E. Daugherty: Assessment of chemical exposure, calculation
methods for environmental professionals, Lewis Publishers, New
York, 1998
 

課程目標
本課程討論化學危害經由環境介質影響人類健康的風險;解釋風險的意義;說明量化風險的過程(危害鑑定、劑量效應分析、暴露評估、風險描述);並且議論風險量化過程所牽涉的概念、術語、方法學、模式及應用軟體。全程以講述及舉例練習的方式進行。

1.讓學生瞭解風險的技術面意義;
2.讓學生有能力量化暴露劑量;
3.讓學生有能力分析劑量與風險的
關係;
4.讓學生有能力推估及描述終生暴
露低劑量化學物的風險;
5.讓學生有能力推算風險管理上需
要的容許暴露濃度值。
 
課程要求
 
預期每週課後學習時數
 
Office Hours
 
指定閱讀
 
參考書目
1. William H. Hallenbeck: Quantitative risk assessment for
environmental and occupational health (2nd Edition), Lewis
Publishers, New York, 1993
2. Jack E.Daugherty: Assessment of chemical exposures,
calculation methods for environmental professionals, Lewis
Publishers, New York, 1998
3. Principles for the assessment of risks to human health from exposure to
chemicals, Geneva: World Health Organization, 1999
4. Joseph V. Rodricks: Calculated risks:the toxicity and human health risks of
chemicals in our environment, Cambridge; New York: Cambridge University Press,
2007
 
評量方式
(僅供參考)
   
課程進度
週次
日期
單元主題
第1週
2/24  Introduction(Risk, health risk assessment, risk management) 
第2週
3/03  Chemical hazards and risk acceptability 
第3週
3/10  Exposure, exposure assessment, exposure scenario and dose 
第4週
3/17  Quantifying exposure dose 
第5週
3/24  Calculation of human dose rate and dose from human and animal studies 
第6週
3/31  Quantization of response; Calculation of excess risk 
第7週
4/07  Holiday 
第8週
4/14  Midterm examination 
第9週
4/21  Excess risk and dose: Tolerance distribution models 
第10週
4/28  Excess risk and dose: Mechanistic models 
第11週
5/05  Life time risk estimate for sub-experimental dose range 
第12週
5/12  Acceptable concentration 
第13週
5/19  Acceptable concentrations-risk analysis method for non-threshold toxicants 
第14週
5/26  Acceptable concentrations-safety factor (uncertainty factor) method for threshold toxicants 
第15週
6/02  Acceptable concentrations (Benchmark dose derived reference concentration, RfC)-benchmark dose method for threshold toxicants  
第16週
6/09  Application of software to health risk assessment –Monte Carlo Simulation; Demonstration of a case study 
第17週
6/23  Final examination