課程名稱 |
環境衛生風險評估 RISK ASSESSMENT FOR ENVIRONMENTAL HEALTH |
開課學期 |
98-2 |
授課對象 |
公共衛生學院 環境衛生研究所 |
授課教師 |
林嘉明 |
課號 |
EH7012 |
課程識別碼 |
844 M1150 |
班次 |
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學分 |
2 |
全/半年 |
半年 |
必/選修 |
選修 |
上課時間 |
星期三7,8(14:20~16:20) |
上課地點 |
公衛211 |
備註 |
總人數上限:30人 |
Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/982raeh |
課程簡介影片 |
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核心能力關聯 |
本課程尚未建立核心能力關連 |
課程大綱
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課程概述 |
教學目標:本課程透過閱讀、討論、練習等方式,使學生熟悉經由環境與職業
暴露化學有害物的健康風險評估,尤其強調方法論與實務應用。
93學年度第二學期(24/02/2010-23/06/2010)環境衛生(健康)風險評估課程大綱
課程編號:環境衛生風險評估 844M1150
授課教師:林嘉明 TEL:02-23123456 ext 8365
課程助教:林士鈞
日期 內容* 備註*
2/24 Introduction(Risk, health risk assessment, risk management)
3/03 Chemical hazards and risk acceptability
3/10 Exposure, exposure assessment, exposure scenario and dose
3/17 Quantifying exposure dose
3/24 Calculation of human dose rate and dose from human and animal studies
3/31 Quantization of response; Calculation of excess risk
4/07 Holiday
4/14 Midterm examination
4/21 Excess risk and dose: Tolerance distribution models
4/28 Excess risk and dose: Mechanistic models
5/05 Life time risk estimate for sub-experimental dose range
5/12 Acceptable concentration
5/19 Acceptable concentrations-risk analysis method for non-threshold
toxicants
5/26 Acceptable concentrations-safety factor (uncertainty factor) method
for threshold toxicants
6/02 Acceptable concentrations (Benchmark dose derived reference
concentration, RfC)-benchmark dose method for threshold toxicants
6/09 Application of software to health risk assessment –Monte Carlo
Simulation; Demonstration of a case study
6/23 Final examination
參考書籍
1. William H. Hallenbeck: Quantitative risk assessment for
environmental and occupational health (2nd Edition), Lewis
Publisher, New York, 1993
2. Jack E. Daugherty: Assessment of chemical exposure, calculation
methods for environmental professionals, Lewis Publishers, New
York, 1998
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課程目標 |
本課程討論化學危害經由環境介質影響人類健康的風險;解釋風險的意義;說明量化風險的過程(危害鑑定、劑量效應分析、暴露評估、風險描述);並且議論風險量化過程所牽涉的概念、術語、方法學、模式及應用軟體。全程以講述及舉例練習的方式進行。
1.讓學生瞭解風險的技術面意義;
2.讓學生有能力量化暴露劑量;
3.讓學生有能力分析劑量與風險的
關係;
4.讓學生有能力推估及描述終生暴
露低劑量化學物的風險;
5.讓學生有能力推算風險管理上需
要的容許暴露濃度值。
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課程要求 |
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預期每週課後學習時數 |
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Office Hours |
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指定閱讀 |
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參考書目 |
1. William H. Hallenbeck: Quantitative risk assessment for
environmental and occupational health (2nd Edition), Lewis
Publishers, New York, 1993
2. Jack E.Daugherty: Assessment of chemical exposures,
calculation methods for environmental professionals, Lewis
Publishers, New York, 1998
3. Principles for the assessment of risks to human health from exposure to
chemicals, Geneva: World Health Organization, 1999
4. Joseph V. Rodricks: Calculated risks:the toxicity and human health risks of
chemicals in our environment, Cambridge; New York: Cambridge University Press,
2007
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評量方式 (僅供參考) |
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週次 |
日期 |
單元主題 |
第1週 |
2/24 |
Introduction(Risk, health risk assessment, risk management) |
第2週 |
3/03 |
Chemical hazards and risk acceptability |
第3週 |
3/10 |
Exposure, exposure assessment, exposure scenario and dose |
第4週 |
3/17 |
Quantifying exposure dose |
第5週 |
3/24 |
Calculation of human dose rate and dose from human and animal studies |
第6週 |
3/31 |
Quantization of response; Calculation of excess risk |
第7週 |
4/07 |
Holiday |
第8週 |
4/14 |
Midterm examination |
第9週 |
4/21 |
Excess risk and dose: Tolerance distribution models |
第10週 |
4/28 |
Excess risk and dose: Mechanistic models |
第11週 |
5/05 |
Life time risk estimate for sub-experimental dose range |
第12週 |
5/12 |
Acceptable concentration |
第13週 |
5/19 |
Acceptable concentrations-risk analysis method for non-threshold toxicants |
第14週 |
5/26 |
Acceptable concentrations-safety factor (uncertainty factor) method for threshold toxicants |
第15週 |
6/02 |
Acceptable concentrations (Benchmark dose derived reference concentration, RfC)-benchmark dose method for threshold toxicants |
第16週 |
6/09 |
Application of software to health risk assessment –Monte Carlo Simulation; Demonstration of a case study |
第17週 |
6/23 |
Final examination |
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